Antiulcer Activity of Patol Churna against Experimental Gastro-duodenal Ulcers in Rats

Patol churna is a well known ayurvedic formulation of Trichosanthes cucumerina Linn. (cucurbitaceae) administered in case of number of alimentary and liver disorders. It is widely used in Indian folk medicine for variety of disease conditions. The aim of present study was to evaluate the antiulcer activity of 50% ethanolic extract of patol churna (PCE) using various experimental models of gastric and duodenal ulceration in rats. Oral administration of 50% ethanolic extract of patol churna was evaluated in rats against ethanol, aspirin and pylorus ligated gastric ulcers as well as cysteamine-induced duodenal ulcers. In all the models studied, the antiulcer activity of PCE compared with that of cimetidine (100mg/kg, p.o.), an H2 receptor antagonist. PCE showed significant antiulcer activity in ethanol-induced and aspirin-induced gastric ulcer models. In 19 hrs pylorus ligated rats, significant reduction in ulcer index, total acidity and pepsin activity was observed with PCE, when compared with the control group. Mucosal defensive factors such as pH, mucin activity and gastric wall mucous content was found to be increased with PCE. PCE was also, afforded remarkable protection in cysteamine-induced duodenal lesions. The antiulcer activity of PCE was comparable with that of cimetidine. Thus, patol churna extract possess significant antiulcer activity against both gastric and duodenal ulcers in rats. The antiulcer activity may be attributed to its cytoprotective action and inhibition of acid secretary parameters. *Corresponding author: Varsha J Galani, Department of Pharmacology, A.R College of Pharmacy, Vallabh Vidyanagar-388120, Gujarat, India, Fax: 02692230788; E-mail: [email protected] Received December 27, 2011; Accepted December 30, 2011; Published January 13, 2012 Citation: Galani VJ, Goswami SS, Shah MB (2011) Antiulcer Activity of Patol Churna against Experimental Gastro-duodenal Ulcers in Rats. J Homeop Ayurv Med 1:105. doi:10.4172/2167-1206.1000105 Copyright: © 2011 Galani VJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.